Inflammation-activated Protein Kinases as Targets for Drug Development

Inflammation-activated protein kinases as targets for drug development.

Given the prevalence and debilitating nature of chronic inflammatory diseases, there is a never-ending quest to identify novel targets for the rational development of antiinflammatory drugs. The major signaling pathway that controls inflammation-associated gene expression is the one which leads to activation of transcription factor nuclear factor-kappaB. Therefore, inhibitors of the kinase resp...

Protein Kinases as Drug Development Targets for Heart Disease Therapy

Protein kinases are intimately integrated in different signal transduction pathways for the regulation of cardiac function in both health and disease. Protein kinase A (PKA), Ca²⁺-calmodulin-dependent protein kinase (CaMK), protein kinase C (PKC), phosphoinositide 3-kinase (PI3K) and mitogen-activated protein kinase (MAPK) are not only involved in the control of subcellular activities for maint...

Protein kinases as drug targets in cancer.

Identification of the key roles of protein kinases in signaling pathways leading to development of cancer has caused pharmacological interest to concentrate extensively on targeted therapies as a more specific and effective way for blockade of cancer progression. This review will mainly focus on inhibitors targeting these key components of cellular signaling by employing a technology-based poin...

Protein Kinases as Drug Targets - ReadingSample

Mitogen activated protein kinases as targets for development of novel anti-inflammatory drugs.

Given the prevalence and debilitating nature of chronic inflammatory diseases there is a never ending quest for identification of novel targets for the rational development of anti-inflammatory drugs. Although the major signalling pathway that controls inflammation associated gene expression is the one leading to activation of transcription factor NF-kappaB, considerable attention has also been...